The New Discovery Might Explain Why Humans Struggle to Regain Strength After Sepsis Recovery
Damage to energy-producing mitochondria might underlie prolonged muscle weakness following a sepsis-like condition in mice, in accordance with new research published today in eLife.
The findings might clarify why people struggle to regain energy after sepsis recovery and suggest the necessity for antioxidants or different alternative treatments to revive muscle health.
Sepsis is the result of an infection that moves into the bloodstream and causes an exaggerated immune response, including dangerous inflammation and organ injury. With intensive care and extended hospitalization, some individuals can survive the situation. However, survivors might face chronic weakness and fatigue and discover it difficult to return to work and different regular actions.
To handle this, Owen and her colleagues developed and studied a mouse model of muscle weakness after sepsis recovery. They confirmed that lowered muscle power within the mice was not attributable to a lack of muscle. Additionally, they seemed for signs of ongoing inflammation within the muscles that may contribute to weakness and located that this didn’t seem like the cause.
Instead, they found that power-producing mitochondria within the animals’ muscle cells have been irregular and confirmed signs of ongoing oxidative injury. “This suggests that chronic muscle weakness amongst sepsis survivors is just not attributable to muscle wasting, however rather caused by the loss of muscle quality,” Owen says.
Whereas present therapies for post-sepsis weakness goal to help patients rebuild muscle mass, these outcomes hint on the want for antioxidant therapies or different treatments to restore mitochondrial health in muscles.