Pharmacy-driven assessment discovered greater than half of the patients with reported penicillin allergies had been capable of taking antibiotics from the same drug class quite than resorting to substitutes which may be extra expensive, have extra unwanted side effects and have other downsides, in accordance with research introduced on the ASHP (American Society of Health-System Pharmacists) 54th Midyear Clinical Meeting and Exhibition. The substitution saved one hospital for almost $21,500 by switching 43 sufferers in simply three months.
Penicillin allergic reactions, reported by as much as 10 % of the population, are the most typical drug allergy; however, researchers consider that true penicillin-allergic reaction are literally rarer, with an overall estimated frequency of lower than 1 %.
For the research, Baptist Hospital pharmacists interviewed sufferers with reported allergic reactions after which fastidiously reviewed their treatment history prior to verifying orders for substitute antibiotics. Penicillin is amongst a wide range of antibiotics in a category often known as beta-lactams, and patients who report allergies to penicillin are sometimes handled with broad-spectrum non-beta-lactam alternate options. These alternate options are sometimes costlier and related to extra side effects, elements that probably limit the benefits of antimicrobial stewardship.
In reviewing patient histories throughout a 3-month span, researchers discovered that 68 %, or 43 out of 63 patients, with reported penicillin-allergic reactions, had previously efficiently used different beta-lactams, most frequently cephalosporins — pharmacists really helpful in switching to a beta-lactam antibiotic with 100 % prescriber acceptance. Aztreonam and levofloxacin had been essentially the most generally prescribed non-beta-lactam antibiotics prior to the allergy assessment.
Clinicians want to save these broad-spectrum antibiotics for conditions the place standard treatments are usually not efficient to make sure the bacteria don’t turn out to be resistant to this next line of defense.